Search Result

Results for "

FLT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLT3 (158) Akt (3) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (64) Aurora Kinase (9) Autophagy (19) Bcr-Abl (10) Btk (2) c-Fms (8) c-Kit (28) c-Met/HGFR (9) Casein Kinase (1) Caspase (2) CDK (13) Checkpoint Kinase (Chk) (3) Cytochrome P450 (1) DAPK (1) Discoidin Domain Receptor (4) Drug Metabolite (1) EGFR (3) Ephrin Receptor (1) ERK (1) FAK (1) Ferroptosis (3) FGFR (17) Haspin Kinase (1) HDAC (5) IAP (1) IFNAR (1) IRAK (2) Isotope-Labeled Compounds (4) JAK (15) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) MAP4K (2) MEK (2) MELK (1) Microtubule/Tubulin (1) MNK (1) NO Synthase (1) PDGFR (29) Pim (2) PKA (1) PKC (2) Polo-like Kinase (PLK) (1) PROTACs (7) RAD51 (2) Raf (4) RET (11) ROS Kinase (2) Small Interfering RNA (siRNA) (10) Src (6) STAT (3) Syk (10) TAM Receptor (10) Target Protein Ligand-Linker Conjugates (1) Tie (1) Topoisomerase (1) Trk Receptor (7) VEGFR (44)
By Research Areas:	Cancer (203) Cardiovascular Disease (2) Inflammation/Immunology (19) Neurological Disease (1)

By Targets:

FLT3 (158)

Akt (3)

AMPK (1)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (64)

Aurora Kinase (9)

Autophagy (19)

Bcr-Abl (10)

Btk (2)

c-Fms (8)

c-Kit (28)

c-Met/HGFR (9)

Casein Kinase (1)

Caspase (2)

CDK (13)

Checkpoint Kinase (Chk) (3)

Cytochrome P450 (1)

DAPK (1)

Discoidin Domain Receptor (4)

Drug Metabolite (1)

EGFR (3)

Ephrin Receptor (1)

ERK (1)

FAK (1)

Ferroptosis (3)

FGFR (17)

Haspin Kinase (1)

HDAC (5)

IAP (1)

IFNAR (1)

IRAK (2)

Isotope-Labeled Compounds (4)

JAK (15)

Ligands for E3 Ligase (1)

Ligands for Target Protein for PROTAC (1)

MAP4K (2)

MEK (2)

MELK (1)

Microtubule/Tubulin (1)

MNK (1)

NO Synthase (1)

PDGFR (29)

Pim (2)

PKA (1)

PKC (2)

Polo-like Kinase (PLK) (1)

PROTACs (7)

RAD51 (2)

Raf (4)

RET (11)

ROS Kinase (2)

Small Interfering RNA (siRNA) (10)

Src (6)

STAT (3)

Syk (10)

TAM Receptor (10)

Target Protein Ligand-Linker Conjugates (1)

Tie (1)

Topoisomerase (1)

Trk Receptor (7)

VEGFR (44)

By Research Areas:

Cancer (203)

Cardiovascular Disease (2)

Inflammation/Immunology (19)

Neurological Disease (1)

225

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1516

Alovudine 3'-Fluoro-3'-deoxythymidine; 3′-Deoxy-3′-fluorothymidine; FLT
Alovudine (3'-Fluoro-3'-deoxythymidine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than ¹⁸F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus activity .

HY-162032

FLT3-IN-25	FLT3	Cancer
FLT3-IN-25 (compound 17) is a potent inhibitor of *FLT3, with IC₅₀s of 1.2 nM, 1.4 nM and 1.1 nM for FLT3-WT, FLT3-D835Y and FLT3-ITD, respectively. FLT*3-IN-25 plays an important role in acute myeloid leukemia (AML) .

HY-144777

FLT3-IN-14	FLT3 Apoptosis	Cancer
FLT3-IN-14 is a potent *FLT3* inhibitor with IC₅₀s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model .

HY-156410

FLT3-IN-23	FLT3	Cancer
FLT3-IN-23 (compound 15) is an inhibitor of JFMS-like tyrosine kinase 3 (FLT3) with an IC₅₀ of 7.42 nM. FLT3-IN-23 has antiproliferative activities against BaF3 cells carrying various FLT3-TKD and FLT3-ITD-TKD mutations .

HY-155770

FLT3-IN-20	FLT3	Cancer
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor with IC₅₀ values of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-20 has anti-proliferation efficacy in FLT3-ITD-positive AML cell lines MV4-11 and MOLM-13 (7 and 9 nM, respectively) and the MOLM-13 variant (4 nM) with the FLT3-ITD-D835Y mutation. FLT3-IN-20 can be used in research of cancer .

HY-148522

FLT3-IN-18	FLT3	Cancer
FLT3-IN-18 is a potent and selective *FLT3* inhibitor with an IC₅₀ value of 0.003 μM. FLT3-IN-18 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-18 inhibits FLT3 and STAT5 phosphorylation. FLT3-IN-18 has the potential for the research of acute myeloid leukemia (AML) .

HY-112475

Flt-3 Inhibitor III	Tie FLT3	Cancer
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an ₅₀ of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects .

HY-128572

FLT3-IN-6

FLT3 Cancer

FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC₅₀ of 1.336 nM .

FLT3-IN-6	FLT3	Cancer
FLT3-IN-6 is a potent and selective inhibitor of *FLT3-ITD* (FLT3 mutation) with an IC₅₀ of 1.336 nM .

HY-134481

FLT3-IN-10	FLT3	Cancer
FLT3-IN-10 (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 has the potential for the research of FLT3-mutated acute myeloid leukemia (AML) .

HY-146886

FLT3-IN-15	FLT3	Cancer
FLT3-IN-15 is a highly potent and orally active *FLT3* inhibitor with IC₅₀s of 0.87 nM and 0.32 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-15 can be used for researching acute myeloid leukemia .

HY-155302

FLT3-IN-22	FLT3	Cancer
FLT3-IN-22 (compound 22f) is a potent *FLT3* inhibitor with IC₅₀ values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L .

HY-112145

FLT3-IN-3

FLT3 Cancer

FLT3-IN-3 is a potent FLT3 inhibitor with IC₅₀s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.

FLT3-IN-3	FLT3	Cancer
FLT3-IN-3 is a potent *FLT3* inhibitor with IC₅₀s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.

HY-143895

FLT3-IN-12	FLT3	Cancer
FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC₅₀s of 1.48 nM and 2.87 nM for *FLT3-WT* and *FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC₅₀* of 0.75 nM) .

HY-148036

FLT3-IN-16

FLT3 Cancer

FLT3-IN-16 is a potent FLT3 inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

FLT3-IN-16	FLT3	Cancer
FLT3-IN-16 is a potent *FLT3* inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

HY-143894

FLT3-IN-11	FLT3	Cancer
FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC₅₀s of 7.22 nM and 4.95 nM for wild-type FLT3 and *FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT*3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC₅₀ of 3.2 nM) .

HY-153473

FLT3-IN-19

FLT3 Cancer

FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with IC₅₀ of 0.213 nM. FLT3-IN-19 can be used in AML disease research .
HY-163068

FLT3-IN-24

FLT3 Cancer

FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC₅₀ of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects .

FLT3-IN-19	FLT3	Cancer
FLT3-IN-19 (Comp 50) is a potent and selective *FLT3* inhibitor with IC₅₀ of 0.213 nM. FLT3-IN-19 can be used in AML disease research .

FLT3-IN-24	FLT3	Cancer
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC₅₀ of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects .

HY-144710

FLT3/ITD-IN-2	FLT3	Cancer
FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 0.3, 0.4 and 1.0 nM against FLT3 ^D835Y, *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-144711

FLT3/ITD-IN-3	FLT3	Cancer
FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 0.3, 0.4 and 0.9 nM against FLT3 ^D835Y, *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-144709

FLT3/ITD-IN-1	FLT3	Cancer
FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 38.2 nM and 144.1 nM against *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-148070

FLT3-IN-17	FLT3 FAK Cytochrome P450	Cancer
FLT3-IN-17 inhibits CYPs and *FLT3* mutants activity (IC₅₀s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC₅₀ value of 12 nM. FLT3 ligand-2 can be used in the research of cancers .

HY-155226

FLT3-IN-21	FLT3 Apoptosis	Cancer
FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC₅₀: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC₅₀: 5.3 nM). In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%) .

HY-146749

FLT3/TrKA-IN-1	FLT3 Trk Receptor Apoptosis	Cancer
FLT3/TrKA-IN-1 is a potent *FLT3/TrKA* dual kinase inhibitor with the IC₅₀s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows antiproliferative activity in vitro. FLT3/TrKA-IN-1 has the potential for the research of Acute myeloid leukemia (AML) .

HY-143278

FLT3-IN-13	Topoisomerase FLT3 Apoptosis	Cancer
FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and *FLT3* dual inhibitor with IC₅₀ values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia .

HY-146680

FLT3/ITD-IN-4	FLT3 RET CDK MAP4K	Cancer
FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC₅₀ of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research .

HY-18744

FLT3-IN-2

FLT3 Cancer

FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.

FLT3-IN-2	FLT3	Cancer
FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.

HY-162367

FLT3/CHK1-IN-2	FLT3 Checkpoint Kinase (Chk)	Cancer
FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of *FLT3* and CHK1, with IC₅₀s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML) .

HY-115904

FLT3/CDK4-IN-1	CDK FLT3	Cancer
FLT3/CDK4-IN-1 is a potent, high selective and orally active *FLT3/CDK4* dual inhibitor (IC₅₀=11 and 7 nM for FLT3 and CDK4, respectively). FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo .

HY-128571

FLT3-IN-4

FLT3 Cancer

FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC₅₀=7 nM) inhibitor for treating acute myelogenous leukemia .

FLT3-IN-4	FLT3	Cancer
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC₅₀=7 nM) inhibitor for treating acute myelogenous leukemia .

HY-155195

FLT3/CHK1-IN-1	Others	Cancer
FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC₅₀ value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells .

HY-161323

FLT3-ITD/D835Y-IN-1	FLT3 Bcr-Abl Apoptosis	Cancer
FLT3-ITD/D835Y-IN-1 (Compound 1) is a *FLT3-ITD* and BCR-ABL inhibitor. FLT3-ITD/D835Y-IN-1 mediates proapoptosis by inhibiting the FLT3 and BCR-ABL pathways, as well as other possible targets. FLT3-ITD/D835Y-IN-1 can be used in the study of acute myeloid leukemia (AML) .

HY-143434

FLT3/D835Y-IN-1	FLT3	Cancer
FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective *FLT3* and *FLT3/D835Y* inhibitor, with IC₅₀ values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia) .

HY-12960

SKLB4771 FLT3-IN-1	FLT3 c-Kit Apoptosis	Cancer
SKLB4771 is a potent and selective Flt3 inhibitor with an IC₅₀ value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue .

HY-RS04987

FLT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT1 Human Pre-designed siRNA Set A contains three designed siRNAs for FLT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT1 Human Pre-designed siRNA Set A FLT1 Human Pre-designed siRNA Set A

HY-RS04988

Flt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Flt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt1 Mouse Pre-designed siRNA Set A Flt1 Mouse Pre-designed siRNA Set A

HY-RS04989

Flt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Flt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt1 Rat Pre-designed siRNA Set A Flt1 Rat Pre-designed siRNA Set A

HY-RS04990

FLT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT3 Human Pre-designed siRNA Set A contains three designed siRNAs for FLT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT3 Human Pre-designed siRNA Set A FLT3 Human Pre-designed siRNA Set A

HY-RS04991

Flt3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Flt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt3 Mouse Pre-designed siRNA Set A Flt3 Mouse Pre-designed siRNA Set A

HY-RS04992

Flt3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Flt3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt3 Rat Pre-designed siRNA Set A Flt3 Rat Pre-designed siRNA Set A

HY-RS04994

FLT4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT4 Human Pre-designed siRNA Set A contains three designed siRNAs for FLT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT4 Human Pre-designed siRNA Set A FLT4 Human Pre-designed siRNA Set A

HY-RS04995

Flt4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Flt4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt4 Mouse Pre-designed siRNA Set A Flt4 Mouse Pre-designed siRNA Set A

HY-RS04996

Flt4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Flt4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt4 Rat Pre-designed siRNA Set A Flt4 Rat Pre-designed siRNA Set A

HY-RS04993

FLT3LG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT3LG Human Pre-designed siRNA Set A contains three designed siRNAs for FLT3LG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT3LG Human Pre-designed siRNA Set A FLT3LG Human Pre-designed siRNA Set A

HY-148521

*PROTAC FLT3/CDK9 degrader-1*	CDK FLT3 PROTACs Apoptosis	Cancer
PROTAC FLT3/CDK9 degrader-1 is a potent *FLT3* and CDK9 dual PROTAC degrader. PROTAC FLT3/CDK9 degrader-1 induces apoptosis and effective degradation of target proteins FLT3 and CDK9. PROTAC FLT3/CDK9 degrader-1 has the potential for the research of FLT3-ITD mutated AML .

HY-130247

*JAK2/FLT3-IN-1* 1 Publications Verification	JAK FLT3 Apoptosis	Cancer
JAK2/FLT3-IN-1 is a potent and orally active dual *JAK2/FLT3* inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity .

HY-161280

*PROTAC FLT-3 degrader 3*	PROTACs FLT3	Cancer
PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of *FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC₅₀* of 7.55 nM in MV4-11 cells .

HY-130247A

*JAK2/FLT3-IN-1 TFA* 1 Publications Verification	JAK FLT3 Apoptosis	Cancer
JAK2/FLT3-IN-1 (TFA) is a potent and orally active dual *JAK2/FLT3* inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity .

HY-114323

*PROTAC FLT-3 degrader 1*	PROTACs FLT3 Apoptosis	Cancer
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC *FLT-3* internal tandem duplication (ITD) degrader with an IC₅₀ 0.6 nM. Anti-proliferative activity; apoptosis induction .

HY-145903

*PDGFRα/FLT3-ITD-IN-2*	PDGFR FLT3	Cancer
PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .

HY-145904

*PDGFRα/FLT3-ITD-IN-3*	PDGFR FLT3	Cancer
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107417

Hypothemycin	Structural Classification Monophenols Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Disease Research Disease Research Fields Cancer	VEGFR MEK FLT3 PDGFR ERK
Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K_is of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, *FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2*, respectively .

HY-N0071

Crotonoside Isoguanosine	Alkaloids Structural Classification Classification of Application Fields Croton tiglium Linn. Source classification Euphorbiaceae Plants Disease Research Fields Cancer	FLT3 HDAC
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits *FLT3* and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML .

HY-N10221

Petromurin C	Alkaloids Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Petromurin C is a bisindolylbenzenoid compound isolated from the ascostromata of Petromycesmuricatus. Petromurin C induces protective autophagy and apoptosis in FLT3-ITD-positive AML .

Species:	Human (34) Rhesus Macaque (3) Mouse (13) Rat (4) Cynomolgus (1) Pig (1)
Tag:	His (36) Tag Free (4) Avi (10) Fc (15)
Source:	HEK293 (44) CHO (2) Sf9 insect cells (3) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P78230

	VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi) FLT; FLT1; FLT-1; FRT; VEGF R1; VEGFR1	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 730 a.a., with molecular weight of 100-120 kDa.

HY-P78537

	VEGFR-1 Protein, Human (HEK293, His-Avi) FLT; FLT1; FLT-1; FRT; VEGF R1; VEGFR1	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of VEGFR-1 Protein, Human (HEK293, His-Avi) is 730 a.a., with molecular weight of 100-120 kDa.

HY-P73554

	VEGFR-1 Protein, Human (756a.a, HEK293, His) Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (756a.a, HEK293, His) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Human (756a.a, HEK293, His) is 756 a.a., with molecular weight of 110-120 kDa.

HY-P73065

	VEGFR-1 Protein, Human (328a.a, HEK293, His) Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (328a.a, HEK293, His) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Human (328a.a, HEK293, His) is 328 a.a., with molecular weight of ~35.6 kDa.

HY-P73064

	VEGFR-1 Protein, Human (328a.a, HEK293, Fc) Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (328a.a, HEK293, Fc) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-1 Protein, Human (328a.a, HEK293, Fc) is 328 a.a., with molecular weight of ~61.1 kDa.

HY-P73553

	VEGFR-1 Protein, Mouse (HEK293, His) Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1	Mouse	HEK293
	The VEGFR-1 protein is a key tyrosine protein kinase receptor. VEGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived VEGFR-1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of VEGFR-1 Protein, Mouse (HEK293, His) is 737 a.a., with molecular weight of ~130 kDa.

HY-P73552

	VEGFR-1 Protein, Rat (HEK293, His) Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1	Rat	HEK293
	VEGFR-1 protein is a tyrosine protein kinase receptor for VEGFA, VEGFB, and PGF and is critical for embryonic vasculature development, angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer invasion. It actively regulates postnatal retinal vitreous vascular degeneration and may act as a negative regulator of embryonic angiogenesis. VEGFR-1 Protein, Rat (HEK293, His) is the recombinant rat-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Rat (HEK293, His) is 736 a.a., with molecular weight of ~110-130 kDa.

HY-P700072

	FLT3LG Protein, Human (Tag Free) FLT-3 Ligand; FLT3 ligand; FL; SL cytokine; FLT-3L	Human	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (Tag Free) is the recombinant human-derived FLT3LG protein, expressed by E. coli, with tag free. The total length of FLT3LG Protein, Human (Tag Free) is 155 a.a., with molecular weight of ~17.61 kDa.

HY-P78872

	*VEGFR-3/FLT4 Protein, Human (Biotinylated, HEK293, His-Avi)* FLT-4; FLT4; LMPH1A; PCLFLT41; VEGFR3; VEGFR-3; FLT-4; FLT-41; FLT41; PCL	Human	HEK293
	VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Human (Biotinylated, HEK293, His-Avi) is 752 a.a., with molecular weight of 115-130 kDa.

HY-P700072AF

	*Animal-Free FLT3LG Protein, Human (His)* FLT-3 Ligand; FLT3 ligand; FL; SL cytokine; FLT-3L	Human	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. Animal-Free FLT3LG Protein, Human (His) is the recombinant human-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FLT3LG Protein, Human (His) is 155 a.a., with molecular weight of ~18.6 kDa.

HY-P78298

	FLT3LG Protein, Mouse (163a.a, HEK293, Fc) FL; FLT3 ligand; FLT3L; FLT3LG; SL cytokine	Mouse	HEK293
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (163a.a, HEK293, Fc) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3LG Protein, Mouse (163a.a, HEK293, Fc) is 163 a.a., with molecular weight of 55-65 kDa.

HY-P7111

	FLT3LG Protein, Human (CHO) 1 Publications Verification rHuFLT-3 Ligand; FLT3 ligand; FL; SL cytokine; FLT-3L	Human	CHO
	FLT3LG Protein, Human (CHO) is a cytokine, which can promote the generation and differentiation of hematopoietic stem cells and their progenitor cells.

HY-P70544

	FLT3LG Protein, Human (HEK293, His) Fms-Felated Tyrosine Kinase 3 Ligand; FLT3 Ligand; FLT3L; SL Cytokine; FLT3LG	Human	HEK293
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FLT3LG Protein, Human (HEK293, His) is 158 a.a., with molecular weight of 24-32 kDa.

HY-P73066

	FLT3LG Protein, Human (sf9, His) Fms-related tyrosine kinase 3 ligand; FLT3 Ligand; FLT3L; SL Cytokine; FLT3LG	Human	Sf9 insect cells
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (sf9, His) is the recombinant human-derived FLT3LG protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of FLT3LG Protein, Human (sf9, His) is 159 a.a., with molecular weight of ~27 kDa.

HY-P73067

	FLT3LG Protein, Mouse (HEK293, Fc) Fms-related tyrosine kinase 3 ligand; FLT3 Ligand; FLT3L; SL Cytokine; FLT3LG	Mouse	HEK293
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3LG Protein, Mouse (HEK293, Fc) is 162 a.a., with molecular weight of ~35 & 55-65 kDa, respectively.

HY-P74150

	FLT3LG Protein, Rat (sf9, His) Fms-related tyrosine kinase 3 ligand; FLT3 Ligand; FLT3L; SL Cytokine; FLT3LG	Rat	Sf9 insect cells
	The FLT3LG protein has the same protein-binding and receptor tyrosine kinase-binding activities predicted to positively regulate natural killer cell proliferation. Intended to be located on the cell surface and extracellular space, it serves as an intrinsic component on the outside of the plasma membrane. FLT3LG Protein, Rat (sf9, His) is the recombinant rat-derived FLT3LG protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FLT3LG Protein, Rat (sf9, His) is 162 a.a., with molecular weight of ~19.7 kDa.

HY-P700238AF

Animal-Free Flt-3 Ligand Protein, Pig (His)

Fms-Felated Tyrosine Kinase 3 Ligand; FLT3 Ligand; FLT3L; SL Cytokine; FLT3LG
Pig E. coli

HY-P72802

	FLT3LG Protein, RhesusMacaque Fms related receptor tyrosine kinase 3 ligand; FLT3LG; FLT-3 Ligand	Rhesus Macaque	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, RhesusMacaque is the recombinant Rhesus Macaque-derived FLT3LG protein, expressed by E. coli , with tag free. The total length of FLT3LG Protein, RhesusMacaque is 159 a.a., with molecular weight of ~18.0 kDa.

HY-P701290

	*FITC-Labeled FLT3 Protein, Human (HEK293, Fc)* FLT-3; Flk-2; STK-1; CD135; FLK2; FLT-3	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FITC-Labeled FLT3 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled FLT3 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled FLT3 Protein, Human (HEK293, Fc) is 517 a.a., with molecular weight of 110-130 kDa & 250 kDa, respectively.

HY-P70563

	FLT3LG Protein, Mouse (HEK293, His) Fms-related tyrosine kinase 3 ligand (FLT3L); SL cytokine; FLT3 ligand;	Mouse	HEK293
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FLT3LG Protein, Mouse (HEK293, His) is 162 a.a., with molecular weight of ~22-33 kDa.

HY-P78538

	*VEGFR-3/FLT4 Protein, Human (HEK293, His-Avi)* VEGFR-3; FLT-4; LMPH1A; PCLFLT41; VEGFR3; FLT-41; PCL	Human	HEK293
	VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Human (HEK293, His-Avi) is 752 a.a., with molecular weight of 110-130 kDa.

HY-P700722

	FLT3 Protein, Cynomolgus (HEK293, hFc) CD135; FLK2; STK-1; FLT-3	Cynomolgus	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3 Protein, Cynomolgus (HEK293, hFc) is 514 a.a., with molecular weight of 160-180 kDa.

HY-P70544G

	*GMP FLT3LG Protein, Human (HEK293, His)* Fms-related tyrosine kinase 3 ligand; FLT3L; SL cytokine; FLT3LG	Human	HEK293
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. GMP FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP FLT3LG Protein, Human (HEK293, His) is 158 a.a., with molecular weight of 24-32 kDa.

HY-P70178

	FLT3 Protein, Human (HEK293, Fc) 2 Publications Verification rHuReceptor-Type Tyrosine-Protein Kinase FLT3/FLT3, Fc; Receptor-Type Tyrosine-Protein Kinase FLT3; FL Cytokine Receptor; Fetal Liver Kinase-2; FLK-2; Fms-Like Tyrosine Kinase 3; FLT-3; Stem Cell Tyrosine Kinase 1; STK-1; CD135; FLT3; FLK2; STK1	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (HEK293, Fc) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3 Protein, Human (HEK293, Fc) is 515 a.a., with molecular weight of ~120.0 kDa.

HY-P78444

	FLT3 Protein, Human (HEK293, His-Avi) CD135; FLK2; STK-1; FLT-3	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FLT3 Protein, Human (HEK293, His-Avi) is 515 a.a., with molecular weight of 75-100 kDa.

HY-P74151

	FLT3 Protein, Mouse (HEK293, His) CD135; FL cytokine receptor; FLK2; Flk-2; FLT-3; STK-1	Mouse	HEK293
	FLT3, a receptor tyrosine kinase, has diverse functions including kinase activation, PI3K binding, and ligase binding. It plays a vital role in hematopoiesis, immune function, and tissue development. FLT3 is expressed in various tissues like the brain, immune system, and reproductive system. It is involved in diseases like leukemia and cancer. The wide functions and tissue-specific expression emphasize FLT3's importance in health and disease. FLT3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLT3 Protein, Mouse (HEK293, His) is 517 a.a., with molecular weight of approximately 88-100 kDa.

HY-P74466

	*VEGFR-3/FLT4 Protein, Mouse (HEK293, His)* Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4	Mouse	HEK293
	VEGFR-3/FLT4 proteins are tyrosine protein kinase receptors for VEGFC and VEGFD and are critical in adult lymphangiogenesis and embryonic vascular development. It promotes endothelial cell function, angiogenesis, and forms a positive feedback loop that increases VEGFC production. VEGFR-3/FLT4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Mouse (HEK293, His) is 751 a.a., with molecular weight of 95-105 kDa.

HY-P74467

	*VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc)* Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4	Mouse	HEK293
	VEGFR-3/FLT4 proteins are tyrosine protein kinase receptors for VEGFC and VEGFD and are critical in adult lymphangiogenesis and embryonic vascular development. It promotes endothelial cell function, angiogenesis, and forms a positive feedback loop that increases VEGFC production. VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc) is 751 a.a., with molecular weight of 115-160 kDa.

HY-P74468

	*VEGFR-3/FLT4 Protein, Human (HEK293, His)* Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4	Human	HEK293
	VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Human (HEK293, His) is 752 a.a., with molecular weight of ~130 kDa.

HY-P74469

	*VEGFR-3/FLT4 Protein, Human (HEK293, hFc)* Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4	Human	HEK293
	VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (HEK293, hFc) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-3/FLT4 Protein, Human (HEK293, hFc) is 752 a.a., with molecular weight of ~160 & 85 & 75 kDa, respectively.

HY-P75183

	FLT3 Protein, Human (T227M, HEK293, His) CD135; FL cytokine receptor; FLK2; Flk-2; FLT-3; STK-1	Human	HEK293
	FLT3, a tyrosine-protein kinase receptor, regulates hematopoietic progenitor cells and dendritic cells' differentiation, proliferation, and survival. It phosphorylates downstream effectors like SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. Additionally, it plays a pivotal role in the phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A/B. Wild-type FLT3 activation modestly activates STAT5A or STAT5B, while constitutive kinase mutations heighten cell proliferation and resist apoptosis, highlighting its role in fostering aberrant signaling pathways. FLT3 Protein, Human (T227M, HEK293, His) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag and T227M mutation. The total length of FLT3 Protein, Human (T227M, HEK293, His) is 515 a.a., with molecular weight of 85-95 kDa.

HY-P75184

	FLT3 Protein, Human (T227M, HEK293, hFc) CD135; FL cytokine receptor; FLK2; Flk-2; FLT-3; STK-1	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (T227M, HEK293, hFc) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3 Protein, Human (T227M, HEK293, hFc) is 517 a.a., with molecular weight of 100-145 kDa.

HY-P7354

	FLT3LG Protein, Mouse (CHO, His) rMuFLT-3 Ligand, His; Fms-related tyrosine kinase 3 ligand; SL cytokine; FLT3lg	Mouse	CHO
	FLT3LG Protein, Mouse (CHO, His) is a ligand of mouse Flt-3, induces proliferation of haematopoietic progenitor cells.

HY-P700177AF

	*Animal-Free FLT3LG Protein, Mouse (His)* rMuFLT-3 Ligand, His; Fms-related tyrosine kinase 3 ligand; SL cytokine; FLT3lg	Mouse	E. coli
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. Animal-Free FLT3LG Protein, Mouse (His) is the recombinant mouse-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FLT3LG Protein, Mouse (His) is 162 a.a., with molecular weight of ~19.3 kDa.

HY-P70501

	VEGF-CC Protein, Human (196a.a, HEK293, His) Vascular Endothelial Growth Factor C; VEGF-C; FLT4 Ligand; FLT4-L; Vascular Endothelial Growth Factor-Related Protein; VRP; VEGFC	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (196a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-CC Protein, Human (196a.a, HEK293, His) is 196 a.a., with molecular weight of 25-30 kDa.

HY-P77864

	VEGF-C Protein, Human (HEK293, His-Avi) VEGFC; VEGF-CC; VEGFc; FLT4-L; VRP	Human	HEK293
	VEGF-C Protein, a crucial member of the PDGF/VEGF growth factor family, plays a role in vital cellular signaling pathways. As part of this family, VEGF-C likely shares characteristics with related proteins, promoting cell growth, angiogenesis, and lymphangiogenesis. Membership in the PDGF/VEGF growth factor family underscores its role in vascular and lymphatic development regulation. Studying VEGF-C enhances understanding of its functions, potential therapeutic applications, and impact on tissue development. Further exploration can deepen comprehension of VEGF-C's contribution to physiological and pathological conditions. VEGF-C Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of VEGF-C Protein, Human (HEK293, His-Avi) is 125 a.a., with homodimer molecular weight of ~23-30 kDa.

HY-P77865

	VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) VEGFC; VEGF-CC; VEGFc; FLT4-L; VRP	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is 125 a.a., with homodimer molecular weight of ~23-30 kDa.

HY-P74474

	VEGF-CC Protein, Mouse/Rat (HEK293, His) FLT4-L; vascular endothelial growth factor C; VEGFC; VRP	Mouse;Rat	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, His) is the recombinant mouse, rat-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-CC Protein, Mouse/Rat (HEK293, His) is 116 a.a., with molecular weight of 14-23 kDa.

HY-P74475

	VEGF-CC Protein, Mouse/Rat (HEK293, Fc) FLT4-L; vascular endothelial growth factor C; VEGFC; VRP	Rat;Mouse	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is the recombinant rat, mouse-derived VEGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is 116 a.a., with molecular weight of ~44 & 34 kDa, respectively.

HY-P70636

	VEGFR-1 Protein, Human (730a.a, HEK293, Fc) 1 Publications Verification Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular permeability factor receptor	Human	HEK293
	The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (730a.a, HEK293, Fc) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-1 Protein, Human (730a.a, HEK293, Fc) is 730 a.a., with molecular weight of 150-175 kDa.

HY-P700635

	FGFR-1 alpha Protein, Human (HEK293, C-His) rHuFGFR-1α, Fc Chimera; BFGFR; CD331; FLT-2	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha Protein, Human (HEK293, C-His) is the recombinant human-derived FGFR-1 alpha protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFR-1 alpha Protein, Human (HEK293, C-His) is 355 a.a., with molecular weight of 41.6 kDa.

HY-P702754

	FLT3 Protein, Human (Biotinylated, sf9, His, Avi) FLT3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2	Human	Sf9 insect cells

HY-P7313

	VEGF-CC Protein, Human (116a.a, HEK293) rHuVEGF-C; Vascular endothelial growth factor C; FLT4-L; VRP	Human	HEK293
	VEGF-C Protein, Human (116a.a, HEK293) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

HY-P73529

	VEGF-CC Protein, Human (125a.a, HEK293, His) FLT4-L; vascular endothelial growth factor C; VEGFC; VRP	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (125a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGF-CC Protein, Human (125a.a, HEK293, His) is 125 a.a., with molecular weight of ~22.5 kDa.

HY-P7313A

	VEGF-CC Protein, Human (116a.a, HEK293, His) rHuVEGF-C; Vascular endothelial growth factor C; FLT4-L; VRP	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-C Protein, Human (116a.a, HEK293, His) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-C Protein, Human (116a.a, HEK293, His) is 116 a.a., with molecular weight of ~19.42 kDa.

HY-P75767

	FGFR-1 Protein, Mouse (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-1 Protein, Mouse (HEK293, Fc) is 376 a.a., with molecular weight of 100-110 kDa.

HY-P75768

	FGFR-1 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-1 Protein, Mouse (HEK293, His) is 355 a.a., with molecular weight of 60-80 kDa.

HY-P75769

	FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is 283 a.a., with molecular weight of ~56.2 kDa.

HY-P75770

	FGFR-1 Protein, Rhesus Macaque (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-1 Protein, Rhesus Macaque (HEK293, His) is 262 a.a., with molecular weight of 50-75 kDa.

HY-P700720

	FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGFR-1; BFGFR; bFGF-R-1; FLT-2; N-sam; CD331;	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 198 a.a., with molecular weight of 45-55 kDa.

Cat. No.	Product Name	Chemical Structure

HY-12432S1

Gilteritinib-d8

Gilteritinib-d₈ is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

HY-13016S

Cabozantinib-d6
Cabozantinib-d₆ is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively[1][2][3].

HY-10260S1

Vandetanib-d4
Vandetanib-d₄ is the deuterium labeled Vandetanib. Vandetanib (ZD6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1][2].

HY-10260S

Vandetanib-d6
Vandetanib-d₆ is the deuterium labeled Vandetanib. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1].

HY-13016S1

Cabozantinib-d4
Cabozantinib-d₄ is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

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